How to develop a novel medical diagnostic for a disease that is inaccurately defined?
Simple blood tests are very helpful in medical decision making. Physicians define a disease based on the clinical course of the patient. Companies collect blood samples from patients hoping to develop diagnostics for the disease, i.e., classifiers that discriminate disease from non-disease. However, in many cases, the clinical definition of disease does not accurately reflect the underlying biology and scientists are faced with the problem of developing a new diagnostic test whose success requires an altered definition of disease.
The following is a link to the PowerPoint presentation (ppt file extension).